About Us
A father-son team bringing DMPK expertise to drug discovery projects
-
ADME/DMPK analysis & strategy
-
Implementation of free drug principles
-
Human PK & Dose-to-Man prediction
-
IND, clinical & regulatory DMPK
Kevin
Kevin has worked in the pharmaceutical industry for 42 years. Throughout that time he has worked extensively in the drug metabolism field, especially as it relates to drug discovery support.
His major area of expertise is in the modulation of physicochemistry to affect drug disposition and in prediction of human pharmacokinetics. He is author on over 50 peer reviewed publications.
Kevin joined the Department of Drug Metabolism at Pfizer Sandwich UK on 1st September 1983, directly from his BSC in Biochemistry at the University of London. His early career involved developing a fundamental understanding of the basics of DMPK support to discovery and development projects. This included developing expertise in small molecule bioanalysis, completion of radiolabelled ADME studies and direct DMPK support to discovery and development projects. He transferred to Pfizer in Boston Mass in 2010 supporting Cardiovascular, Inflammation and Immunology and Rare Disease Therapeutic Areas.
After 9 years in the US, Kevin returned to the UK and for the last 5 years worked with AstraZeneca supporting Oncology R&D with DMPK expertise.
Mike
Mike graduated from the University of Manchester with a 1st Class (Hons.) MChem chemistry degree, followed by a PhD. in catalysis, reaction mechanism determination and synthesis from the University of Liverpool.
He has nearly 10 years experience in preclinical drug discovery at C4X Discovery, a biotech. Starting out in molecular modelling and computational chemistry, he moved into compound design, especially focussed on physicochemical properties and improving ADME/DMPK profiles. He has worked on >10 drug discovery projects, across multiple disease areas, including as a lead compound designer on a project from HitID through to candidate selection and as project lead on a Hit-to-Lead program.
